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Lebeau, Michelle M.
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overview Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of haploinsufficient myeloid leukemia-related genes involved in the del(5q) characteristic of therapy-related acute myeloid leukemia; development and characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing.
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Item TypeName
Concept Acute Disease
Concept Actins
Concept Breast Neoplasms
Concept Amino Acid Sequence
Concept Antigens, Surface
Concept Antineoplastic Agents
Concept Animals
Concept Antineoplastic Combined Chemotherapy Protocols
Concept Androgens
Concept Chromosome Banding
Concept Chromosomes, Human, Pair 11
Concept Chromosomes, Human, Pair 2
Concept Chromosomes, Human, Pair 6
Concept Chromosomes, Human, Pair 8
Concept Base Sequence
Concept Benzamides
Concept DNA Damage
Concept Azacitidine
Concept Binding Sites
Concept Blast Crisis
Concept Biopsy
Concept Cell Division
Concept Chromosomes, Human, Pair 1
Concept Chromosomes, Human, Pair 15
Concept Chromosomes, Human, Pair 21
Concept Chromosomes, Human, Pair 3
Concept Chromosomes, Human, Pair 12
Concept Chromosomes, Human, Pair 14
Concept Cell Transformation, Neoplastic
Concept Chicago
Concept Chromosome Deletion
Concept Chromosomes, Human, Pair 22
Concept Chromosomes, Human, Pair 4
Concept Genes, Homeobox
Concept Chromosomes, Human, Pair 5
Concept Chromosomes, Human, Pair 7
Concept Chromosomes, Human, Pair 20
Concept Clathrin
Concept DNA-Binding Proteins
Concept DNA, Ribosomal
Concept DNA Repair
Concept Down Syndrome
Concept DNA, Neoplasm
Concept Dogs
Concept Erythroblasts
Concept Leukemia
Concept Leukemia, Megakaryoblastic, Acute
Concept Chromosomes, Human, Pair 17
Concept Chromosomes, Human, Pair 9
Concept Chronic Disease
Concept Mammary Neoplasms, Experimental
Concept DNA
Concept Infant, Newborn
Concept Introns
Concept Chromosome Inversion
Concept Karyotyping
Concept DNA (Cytosine-5-)-Methyltransferases
Concept Oncogenes
Concept Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Concept DNA Replication
Concept Eosinophilia
Concept Leukocytes, Mononuclear
Concept Membrane Glycoproteins
Concept Microcephaly
Concept Microfilament Proteins
Concept Mice, Transgenic
Concept Microbodies
Concept Mastocytosis
Concept Muscle, Smooth, Vascular
Concept Intellectual Disability
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Middle East
Concept Repetitive Sequences, Nucleic Acid
Concept Cricetinae
Concept RNA, Transfer, Leu
Concept Philadelphia Chromosome
Concept Phosphatidylinositols
Concept Luciferases
Concept Phytohemagglutinins
Concept Poly A
Concept Muscle Proteins
Concept Prostatic Neoplasms
Concept Protein Conformation
Concept Immunoglobulin Joining Region
Concept Recurrence
Concept Registries
Concept Risk Factors
Concept Sequence Homology, Nucleic Acid
Concept Gene Rearrangement, B-Lymphocyte
Concept Cohort Studies
Concept Polymorphism, Restriction Fragment Length
Concept Humans
Concept Leukemia, Radiation-Induced
Concept Leukocyte Count
Concept Leukopenia
Concept Cluster Analysis
Concept Genes, abl
Concept United States
Concept Syndrome
Concept Trisomy
Concept Germ-Line Mutation
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Leukemia, Myeloid
Concept Oncogene Proteins, Fusion
Concept Risk Assessment
Concept CD11 Antigens
Concept rac1 GTP-Binding Protein
Concept Mutagenesis
Concept Zebrafish Proteins
Concept Antigens, CD
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Lymphoma
Concept Mitochondria
Concept DNA Probes
Concept Leukemia, Myeloid, Acute
Concept Mutagenesis, Site-Directed
Concept Receptors, Cytoadhesin
Concept In Situ Hybridization
Concept Sequence Analysis, DNA
Concept Genes, APC
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Myosins
Concept Neoplasm Metastasis
Concept Genomic Instability
Concept Oligodeoxyribonucleotides
Concept Consensus Sequence
Concept Interferon-alpha
Concept Gene Deletion
Concept Sequence Deletion
Concept Mice, Knockout
Concept DNA, Complementary
Concept Disease Progression
Concept Helix-Loop-Helix Motifs
Concept beta Catenin
Concept Hepatocyte Nuclear Factor 1-alpha
Concept Antineoplastic Agents, Alkylating
Concept MAP Kinase Kinase Kinases
Concept Mutation, Missense
Concept In Situ Hybridization, Fluorescence
Concept Chromosome Breakpoints
Concept Integrin alpha Chains
Concept Proprotein Convertase 2
Concept NIH 3T3 Cells
Concept COS Cells
Concept CD58 Antigens
Concept Oligonucleotide Array Sequence Analysis
Concept Wnt Proteins
Concept Adenomatous Polyposis Coli Protein
Concept Progeria
Concept Promoter Regions, Genetic
Concept Mice
Concept Early Growth Response Protein 1
Concept DNA Breaks, Double-Stranded
Concept RNA, Messenger
Concept Lamin Type A
Concept Rats
Concept Spleen
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Zebrafish
Concept Colorectal Neoplasms
Concept Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept Leukemia, Promyelocytic, Acute
Concept Multivariate Analysis
Concept Survival Analysis
Concept Lewis X Antigen
Concept Tetradecanoylphorbol Acetate
Concept Mice, 129 Strain
Concept Hominidae
Concept Leukemia-Lymphoma, Adult T-Cell
Concept Leukemia, Myeloid, Chronic-Phase
Concept Gene Expression Regulation, Leukemic
Concept Survival Rate
Concept Fusion Proteins, bcr-abl
Concept Polymerase Chain Reaction
Concept Proto-Oncogene Proteins p21(ras)
Concept Leukemic Infiltration
Concept DNA Methylation
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Myeloid Progenitor Cells
Concept Cell Lineage
Concept Hematologic Neoplasms
Concept K562 Cells
Concept Tandem Repeat Sequences
Concept MAP Kinase Signaling System
Concept Nanoparticles
Concept Haploinsufficiency
Concept RNA, Small Interfering
Concept Thymocytes
Concept Myeloid-Lymphoid Leukemia Protein
Concept fms-Like Tyrosine Kinase 3
Concept Topoisomerase II Inhibitors
Concept Chromosome Aberrations
Concept Chromosomes, Human
Concept Chromosomes, Human, Pair 16
Concept Chromosomes, Human, Pair 18
Concept Disease Models, Animal
Concept Ethylnitrosourea
Concept Follow-Up Studies
Concept Hemoglobinuria, Paroxysmal
Concept Lymphocyte Activation
Concept Lymphocytes
Concept Mice, Mutant Strains
Concept Histone-Lysine N-Methyltransferase
Concept Proto-Oncogenes
Concept Retrospective Studies
Concept T-Lymphocytes
Concept Translocation, Genetic
Concept World Health Organization
Concept Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concept Integrins
Concept Immunophenotyping
Concept Mutagenesis, Insertional
Concept Glycosylphosphatidylinositols
Concept DNA Primers
Concept Genetic Predisposition to Disease
Concept U937 Cells
Concept Polymorphism, Single Nucleotide
Concept MicroRNAs
Academic Article Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia.
Academic Article pMCT108.2 is a chimaeric clone which physically maps to human chromosome bands 9q33 (D9S203) and 18q21.1 (D18S24).
Academic Article Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.
Academic Article Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.
Academic Article Reassignment of pEFD70.3 (D18S23) to human chromosome band 21q22.2 (D21S412) by physical mapping.
Academic Article Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.
Academic Article Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2.
Academic Article Cloning and characterization of MST4, a novel Ste20-like kinase.
Academic Article A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells.
Academic Article Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.
Academic Article Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization.
Academic Article Heritable fragile sites in cancer.
Academic Article Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia.
Academic Article Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB).
Academic Article Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis.
Academic Article Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene.
Academic Article Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells.
Academic Article Localization of prostate cancer metastasis-suppressor activity on human chromosome 17.
Academic Article Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
Academic Article Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia.
Academic Article The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).
Academic Article Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Academic Article Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc.
Academic Article ß-Catenin induces T-cell transformation by promoting genomic instability.
Academic Article Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
Academic Article Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.
Academic Article Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Academic Article Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL).
Academic Article Therapy-related myeloid neoplasms: when genetics and environment collide.
Academic Article DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Academic Article TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends.
Academic Article Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Academic Article Dissecting the role of aberrant DNA methylation in human leukaemia.
Concept Cellular Reprogramming Techniques
Concept CD48 Antigen
Concept Minichromosome Maintenance Proteins
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept Carcinogenesis
Search Criteria
  • DNA
  • Cytosine
  • 5
  • Methyltransferases